And at the heart of Spirits in the Wires are Saskia Madding and Christiana Tree, both of whom are tied to perennial Newford character, the writer Christy Riddell. Are either Saskia or Christiana real? Christy's girlfriend, Saskia, believes she was born in a Web site, while Christiana is Christy's "shadow self" - all the parts of him that he cast out when he was seven years old.

At a popular Newford on-line research and library Web site called the Wordwood, a mysterious "crash" occurs. Everyone visiting the site at the moment of the crash vanishes from where they were sitting in front of their computers. Saskia, disappears right before Christy's eyes.